Limf is a versatile prenyltransferase
Nettet26. nov. 2024 · mutant (LimF-E54A), a Asp70 mutant (LimF-D70 A), and three His172 mutants (LimF-H172 A, LimF-H172 F, and LimF - H172L ) and reacted with the canonical substrate bcLimE2 to check their His - C … Nettet19. des. 2016 · LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates. 15 August 2024. Yuchen Zhang, Keisuke Hamada, ...
Limf is a versatile prenyltransferase
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NettetHere we report a prenyltransferase, LimF, ... LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates. Preprint. Full-text … NettetFor example, dialkyl ketones are difficult to reduce enantioselectively. Here we report a protocol for the highly enantioselective hydrogenation of dialkyl ketones catalysed by a rationally designed chiral spiro iridium complex. The tridentate spiro structure and the bulky phosphino groups of the chiral ligand imparted a remarkable stability ...
Nettet15. aug. 2024 · LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates - Nature Catalysis. His-C2-directed modification is … Nettet1. aug. 2024 · The prenyltransferase LimF has been discovered and applied for geranylation of histidine-containing peptides and imidazole-containing small molecules, …
NettetYeo Joon Yoon, Bradley S Moore, Eunji Kim, 2015, Nature chemical biology. Nettet21. jun. 2024 · We previously reported that dietary supplementation with cholic acid (CA), the primary 12α-hydroxylated (12αOH) bile acid (BA), reduces plasma adiponectin concentration in rats. The aim of...
Nettet9. okt. 2024 · LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates Zhang, Y., Hamada, K., Nguyen, D.T., Inoue, S., …
Nettet1. apr. 2024 · LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates. Nat. Catal., 5 (2024), pp. 682-693. CrossRef View in Scopus Google Scholar. 45. N. Leikoski, et al. Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides. nkst educationNettetThe raw LC-MS data are shown in Fig. S18. from publication: LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates ... nursing homes in pinehurst north carolinaNettetDOI: 10.1016/j.phytochem.2024.112895 Corpus ID: 237198313; A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids. @article{Shi2024ACR, title={A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids.}, author={Shaochun Shi and Jichong … nursing homes in piqua ohio 45356NettetInterestingly, LimF executes the geranylation on not only its native peptide substrate but also a wide range of exotic peptides, including thioether-closed macrocycles. We have also serendipitously uncovered an ability of Tyr-O-geranylation as the secondary function of LimF, indicating it is an unusual bifunctional prenyltransferase. nkt activationNettetDownload scientific diagram The steady-state kinetic parameters for LimF (wild type) and LimF-H172L mutant in different geranylation modes. from publication: LimF is a … nkt alpine pattern porcelainNettet1 LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates Yuchen Zhang1,†, Keisuke 1Hamada2,†, Dinh Thanh Nguyen, … nursing homes in pittsburgh areaNettet5. mar. 1998 · Microcin B17 (MccB17) is a peptidyl antibiotic that is secreted in stationary phase by several strains of Escherichia coli. The antibiotic efficacy of this polypeptide depends on the posttranslational modification of eight cysteine and serine residues to thiazoles and oxazoles, respectively, within the 69 aa McbA structural gene product. … nursing homes in pittsboro nc