Cisplatin clearance
WebJan 11, 2024 · According to current clinical trial eligibility criteria, patients with muscle-invasive bladder cancer (MIBC) and baseline renal clearance of 40–60 ml/min can … WebCombination of Paclitaxel, Ifosfamide, and Cisplatin Is an —文档、资料、论文、办公、总结，均是精品资料，免费阅读，免费分享，值得下载！
Cisplatin clearance
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Webwith three cycles of cisplatin 70 mg/qm2 on day 1 and methotrexate 40 mg/qm2 on days 8 and 15 of a 21-day cycle (CM) or three cycles of methotrexate 30 mg/qm2 on days 1, 15, and 22, vinblastine 3 mg/qm2 on days 2, 15, and 22, epirubicin 45 mg/qm2 on day 2, and cisplatin 70 mg/qm2 on day 2 of a 28-day cycle (M-VEC). Results WebThe intraperitoneal injection of cisplatin increased kidney weight, serum cystatin-c, and serum creatinine, at the same time, decreased body weight, urinary volume, urine creatinine, creatinine clearance, and renal antioxidant activity, all of which were significant.
WebMar 9, 2024 · Currently, societies of nephrology recommend dose reductions in cisplatin for patients with renal insufficiency of creatinine clearance (CrCl) between 30 and 60 mL/min. 10-12 Among their recommendations, unified protocol based on Kintzel's indication is especially popular. 10, 11, 13 Kintzel et al reported an indicator of cisplatin dose ... WebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for …
WebFeb 16, 2016 · All patients were treated with high-dose cisplatin CCRT. The main outcome parameters were nephrotoxicity (defined as creatinine clearance grade 2 or more) and cumulative doses of cisplatin and radiation. Results: 133 patients (64%) completed all pre-planned courses of cisplatin. Nephrotoxicity was the main reason to discontinue the …
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WebALIMTA in combination with cisplatin is indicated for the treatment of chemotherapy naïve patients with unresectable malignant pleural mesothelioma. ... creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients. There are insufficient data on the use of pemetrexed in patients with ... high power led christmas lightsWebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), … how many bivalent boosters are allowedWebMay 18, 2024 · Compared with nonelderly patients, elderly patients (older than 70 years) have slow ultrafilterable cisplatin plasma clearance and persistently high plasma levels of ultrafilterable cisplatin at 48 h after receiving an initial dose of 50–65 mg/m 2. 81 A dose of 80 mg/m 2 cisplatin was administered to patients with lung cancer, and the results … high power led flood lightsWebMean total body clearance was 21 L/h/m 2. Distribution. The initial rapid decline represents distribution to the peripheral compartments and the late (terminal) phase is due, in part, to a relatively slow efflux of docetaxel from the peripheral compartment. Mean steady state volume of distribution was 113 L. ... Cisplatin and Fluorouracil: The ... how many bjs stores are thereWebCisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [ 1 ].... high power led flashlightsWebJan 7, 2024 · As cytotoxic cisplatin levels within a tumor depend heavily on the competition between drug diffusion and clearance, spatial variations in the cisplatin diffusion coefficient and clearance rate ... how many bl series have you watchedWebJul 1, 1982 · The mechanism of renal clearance of cisplatin (cis-dichlorodiammine platinum ii) and its modification by furosemide and probenecid The mechanism of renal … high power led heatsink